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ea0090oc6.6 | Oral Communications 6: Endocrine-related Cancer | ECE2023

Cellular landscape of adrenocortical carcinomas determined by molecular profiling of primary, recurrent and metastatic tumour samples at single-nuclei resolution.

Altieri Barbara , S. Tourigny David , Secener Ali Kerim , Sbiera Silviu , Arampatzi Panagiota , Sauer Sascha , Fassnacht Martin , Ronchi Cristina

Background: Molecular mechanisms of malignant adrenocortical tumorigenesis remain elusive despite previous comprehensive genomic studies. Nonetheless, cellular heterogeneity of primary, recurrent and metastatic adrenocortical carcinoma (ACC) havent been fully investigated.Aim: To characterize the molecular profile of different cell subtypes in primary, recurrent and metastatic ACC by single-nuclei RNA sequencing (snRNA-Seq), using adult human norma...

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ea0081yi2 | Young Investigator Awards | ECE2022

Single-nuclei transcriptome of adult human adrenal glands reveals novel insights into molecular mechanisms intrinsic to adrenocortical tumourigenesis and cortisol secretion

Altieri Barbara , Secener Ali Kerim , Sai Somesh , Fischer Cornelius , Sbiera Silviu , Arampatzi Panagiota , Vitcetz Sarah , Braeuning Caroline , Sauer Sascha , Fassnacht Martin , Ronchi Cristina

Background: Molecular mechanisms underlying the pathogenesis of adrenocortical adenomas (ACAs) and autonomous cortisol secretion remains frequently unexplained despite previous comprehensive genomics studies.Aim: To gain novel insights into molecular pathogenesis of adrenocortical tumours by investigating transcriptome profiles of ACAs at single-nuclei resolution (snRNA-Seq), using adult human normal adrenal glands (NAGs) as reference.<p class="abste...

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Endocrine Abstracts

Cellular landscape of adrenocortical carcinomas determined by molecular profiling of primary, recurrent and metastatic tumour samples at single-nuclei resolution.

Single-nuclei transcriptome of adult human adrenal glands reveals novel insights into molecular mechanisms intrinsic to adrenocortical tumourigenesis and cortisol secretion

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